AustralieFrV1, Main, Exploration, bibRecord, 00AD68

Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension

Identifieur interne : 00AD68 ( Main/Exploration ); précédent : 00AD67; suivant : 00AD69

Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension

Auteurs : Olivier Sitbon [France, Suisse, Australie] ; Virginie Gressin ; Rudolf Speich ; Peter S. Macdonald ; Milos Opravil ; David A. Cooper ; Thierry Fourme ; Marc Humbert ; Jean-Francois Delfraissy ; Gérald Simonneau

Source :

American journal of respiratory and critical care medicine [ 1073-449X ] ; 2004.

RBID : Pascal:05-0016996

Descripteurs français

Pascal (Inist)
- Hypertension artérielle pulmonaire, Réanimation, Soin intensif, SIDA, Bosentan, Traitement, Virus immunodéficience humaine, Dopplérométrie, Echocardiographie, Qualité vie.

English descriptors

KwdEn :
- AIDS, Bosentan, Doppler ultrasound study, Echocardiography, Human immunodeficiency virus, Intensive care, Pulmonary hypertension, Quality of life, Resuscitation, Treatment.

Abstract

Clinical studies have shown the importance of endothelin as a pathogenic mediator in pulmonary arterial hypertension (PAH). We describe the effects of bosentan, an oral dual endothelin receptor antagonist, in patients with PAH associated with human immunodeficiency virus (HIV) infection. In this prospective study, 16 patients with PAH associated with HIV infection in stable condition received bosentan for 16 weeks. Efficacy endpoints included exercise capacity, cardiopulmonary hemodynamics, Doppler echocardiography, New York Heart Association functional class, and quality of life (SF-36 and EQ-5D). Safety was assessed by laboratory tests, vital signs, and adverse events. Improvements were observed from baseline to Week 16 in all efficacy parameters: 6-minute walk distance (+91 ± 60 m, p < 0.001), New York Heart Association class (14 patients improved), hemodynamics (cardiac index: +0.9 ± 0.7 L/minute/m², p < 0.001), Doppler echocardiographic variables, and quality of life. During the study, no patient died and none required epoprostenol treatment. Hepatic tolerability was similar to that reported in patients with PAH. Bosentan had no negative impact on control of HIV infection. Although limited by uncontrolled design, small sample size and short duration, this study suggests that bosentan may benefit patients with PAH associated with HIV infection, and that endothelin is an important pathogenic mediator in this disease.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 004B77
to stream PascalFrancis, to step Curation: 001526
to stream PascalFrancis, to step Checkpoint: 004C59
to stream Main, to step Merge: 00BA86
to stream Main, to step Curation: 00AD68

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension</title>
<author><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hôpital Antoine Béclère</s1>
<s2>Clamart</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Clamart</wicri:noRegion>
<wicri:noRegion>Hôpital Antoine Béclère</wicri:noRegion>
<wicri:noRegion>Hôpital Antoine Béclère</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hôpital de Bicêtre</s1>
<s2>le Kremlin-Bicêtre</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<wicri:noRegion>le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital de Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital de Bicêtre</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Actelion Pharmaceuticals Ltd.</s1>
<s2>Paris</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University Hospital Zurich</s1>
<s2>Zurich</s2>
<s3>CHE</s3>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>University Hospital Zurich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>St. Vincent's Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gressin, Virginie" sort="Gressin, Virginie" uniqKey="Gressin V" first="Virginie" last="Gressin">Virginie Gressin</name>
</author>
<author><name sortKey="Speich, Rudolf" sort="Speich, Rudolf" uniqKey="Speich R" first="Rudolf" last="Speich">Rudolf Speich</name>
</author>
<author><name sortKey="Macdonald, Peter S" sort="Macdonald, Peter S" uniqKey="Macdonald P" first="Peter S." last="Macdonald">Peter S. Macdonald</name>
</author>
<author><name sortKey="Opravil, Milos" sort="Opravil, Milos" uniqKey="Opravil M" first="Milos" last="Opravil">Milos Opravil</name>
</author>
<author><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name>
</author>
<author><name sortKey="Fourme, Thierry" sort="Fourme, Thierry" uniqKey="Fourme T" first="Thierry" last="Fourme">Thierry Fourme</name>
</author>
<author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
</author>
<author><name sortKey="Delfraissy, Jean Francois" sort="Delfraissy, Jean Francois" uniqKey="Delfraissy J" first="Jean-Francois" last="Delfraissy">Jean-Francois Delfraissy</name>
</author>
<author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gérald" last="Simonneau">Gérald Simonneau</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0016996</idno>
<date when="2004">2004</date>
<idno type="stanalyst">PASCAL 05-0016996 INIST</idno>
<idno type="RBID">Pascal:05-0016996</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">004B77</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001526</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">004C59</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">004C59</idno>
<idno type="wicri:doubleKey">1073-449X:2004:Sitbon O:bosentan:for:the</idno>
<idno type="wicri:Area/Main/Merge">00BA86</idno>
<idno type="wicri:Area/Main/Curation">00AD68</idno>
<idno type="wicri:Area/Main/Exploration">00AD68</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension</title>
<author><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hôpital Antoine Béclère</s1>
<s2>Clamart</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Clamart</wicri:noRegion>
<wicri:noRegion>Hôpital Antoine Béclère</wicri:noRegion>
<wicri:noRegion>Hôpital Antoine Béclère</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hôpital de Bicêtre</s1>
<s2>le Kremlin-Bicêtre</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<wicri:noRegion>le Kremlin-Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital de Bicêtre</wicri:noRegion>
<wicri:noRegion>Hôpital de Bicêtre</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Actelion Pharmaceuticals Ltd.</s1>
<s2>Paris</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University Hospital Zurich</s1>
<s2>Zurich</s2>
<s3>CHE</s3>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>University Hospital Zurich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>St. Vincent's Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gressin, Virginie" sort="Gressin, Virginie" uniqKey="Gressin V" first="Virginie" last="Gressin">Virginie Gressin</name>
</author>
<author><name sortKey="Speich, Rudolf" sort="Speich, Rudolf" uniqKey="Speich R" first="Rudolf" last="Speich">Rudolf Speich</name>
</author>
<author><name sortKey="Macdonald, Peter S" sort="Macdonald, Peter S" uniqKey="Macdonald P" first="Peter S." last="Macdonald">Peter S. Macdonald</name>
</author>
<author><name sortKey="Opravil, Milos" sort="Opravil, Milos" uniqKey="Opravil M" first="Milos" last="Opravil">Milos Opravil</name>
</author>
<author><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name>
</author>
<author><name sortKey="Fourme, Thierry" sort="Fourme, Thierry" uniqKey="Fourme T" first="Thierry" last="Fourme">Thierry Fourme</name>
</author>
<author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
</author>
<author><name sortKey="Delfraissy, Jean Francois" sort="Delfraissy, Jean Francois" uniqKey="Delfraissy J" first="Jean-Francois" last="Delfraissy">Jean-Francois Delfraissy</name>
</author>
<author><name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gérald" last="Simonneau">Gérald Simonneau</name>
</author>
</analytic>
<series><title level="j" type="main">American journal of respiratory and critical care medicine</title>
<title level="j" type="abbreviated">Am. j. respir. crit. care med.</title>
<idno type="ISSN">1073-449X</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">American journal of respiratory and critical care medicine</title>
<title level="j" type="abbreviated">Am. j. respir. crit. care med.</title>
<idno type="ISSN">1073-449X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Bosentan</term>
<term>Doppler ultrasound study</term>
<term>Echocardiography</term>
<term>Human immunodeficiency virus</term>
<term>Intensive care</term>
<term>Pulmonary hypertension</term>
<term>Quality of life</term>
<term>Resuscitation</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Hypertension artérielle pulmonaire</term>
<term>Réanimation</term>
<term>Soin intensif</term>
<term>SIDA</term>
<term>Bosentan</term>
<term>Traitement</term>
<term>Virus immunodéficience humaine</term>
<term>Dopplérométrie</term>
<term>Echocardiographie</term>
<term>Qualité vie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Clinical studies have shown the importance of endothelin as a pathogenic mediator in pulmonary arterial hypertension (PAH). We describe the effects of bosentan, an oral dual endothelin receptor antagonist, in patients with PAH associated with human immunodeficiency virus (HIV) infection. In this prospective study, 16 patients with PAH associated with HIV infection in stable condition received bosentan for 16 weeks. Efficacy endpoints included exercise capacity, cardiopulmonary hemodynamics, Doppler echocardiography, New York Heart Association functional class, and quality of life (SF-36 and EQ-5D). Safety was assessed by laboratory tests, vital signs, and adverse events. Improvements were observed from baseline to Week 16 in all efficacy parameters: 6-minute walk distance (+91 ± 60 m, p < 0.001), New York Heart Association class (14 patients improved), hemodynamics (cardiac index: +0.9 ± 0.7 L/minute/m<sup>2</sup>
, p < 0.001), Doppler echocardiographic variables, and quality of life. During the study, no patient died and none required epoprostenol treatment. Hepatic tolerability was similar to that reported in patients with PAH. Bosentan had no negative impact on control of HIV infection. Although limited by uncontrolled design, small sample size and short duration, this study suggests that bosentan may benefit patients with PAH associated with HIV infection, and that endothelin is an important pathogenic mediator in this disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Suisse</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
<li>Sydney</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name>
<name sortKey="Delfraissy, Jean Francois" sort="Delfraissy, Jean Francois" uniqKey="Delfraissy J" first="Jean-Francois" last="Delfraissy">Jean-Francois Delfraissy</name>
<name sortKey="Fourme, Thierry" sort="Fourme, Thierry" uniqKey="Fourme T" first="Thierry" last="Fourme">Thierry Fourme</name>
<name sortKey="Gressin, Virginie" sort="Gressin, Virginie" uniqKey="Gressin V" first="Virginie" last="Gressin">Virginie Gressin</name>
<name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name>
<name sortKey="Macdonald, Peter S" sort="Macdonald, Peter S" uniqKey="Macdonald P" first="Peter S." last="Macdonald">Peter S. Macdonald</name>
<name sortKey="Opravil, Milos" sort="Opravil, Milos" uniqKey="Opravil M" first="Milos" last="Opravil">Milos Opravil</name>
<name sortKey="Simonneau, Gerald" sort="Simonneau, Gerald" uniqKey="Simonneau G" first="Gérald" last="Simonneau">Gérald Simonneau</name>
<name sortKey="Speich, Rudolf" sort="Speich, Rudolf" uniqKey="Speich R" first="Rudolf" last="Speich">Rudolf Speich</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name>
</noRegion>
<name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name>
<name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name>
</noRegion>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00AD68 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00AD68 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:05-0016996
   |texte=   Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension

Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri